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APC KAPS-Paper-1 Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Pharmaceutical Chemistry30%- Physical Pharmacy
  • 1. Physicochemical properties affecting drug action
    • 2. Chemical kinetics and shelf-life
      • 3. Solubility and dissolution
        • 4. Partition coefficient and pH-partition theory
          - Analytical Chemistry
          • 1. Quality control and purity assessment
            • 2. Principles of drug analysis and identification
              - Medicinal and Organic Chemistry
              • 1. Acid-base properties and pKa
                • 2. Drug stability and degradation pathways
                  • 3. Drug classification and nomenclature
                    • 4. Stereochemistry and isomerism
                      • 5. Functional groups and chemical reactivity
                        Topic 2: Physiology and Pharmacology70%- Systemic Pharmacology
                        • 1. Anti-inflammatory, analgesic and immunomodulatory drugs
                          • 2. Central nervous system drugs
                            • 3. Cardiovascular and renal pharmacology
                              • 4. Respiratory and gastrointestinal drugs
                                • 5. Endocrine and metabolic pharmacology
                                  • 6. Autonomic nervous system drugs
                                    - General Pharmacology
                                    • 1. Pharmacokinetics: absorption, distribution, metabolism, excretion
                                      • 2. Mechanisms of drug action and receptor theory
                                        • 3. Drug interactions and adverse effects
                                          • 4. Drug-protein binding and clearance
                                            - Chemotherapy
                                            • 1. Principles of antimicrobial resistance
                                              • 2. Antibacterial, antiviral and antifungal agents
                                                • 3. Antiparasitic and antineoplastic drugs

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